Participant 3: St.Catharine Orthopedics, Surgery, Neurology and Physical Medicine and Rehabilitation Specialty Hospital (St-Cat), Zabok, Croatia / Prof. Dragan Primorac

Specialty Hospital for orthopaedics, neurology and physical medicine and rehabilitation St. Catharine is a regional center of excellence with the latest diagnostic, therapeutic (particularly pain treatment) and rehabilitation infrastructure with an excellent collaboration with leading European and American institutions (Carolines Pain Institute, USA, Diagnostikum, Austria etc..). St. Catherine hospital has a license by Ministry of Science of Croatia to carry out research activities in biomedicine and healthcare. St. Catharine Hospital functions as a teaching base for School of Medicine at Split Osijek Universities.
Team leader is Prof. Dragan Primorac, hospital founder, former Croatian minister of science, education and sports and professor at Split and Osijek Medical School as well as at the Penn State University and University of New Haven.
His group described one of mechanisms of Osteogenesis Imperfecta type I (caused by defective splicing of mRNA from one COL1A1 allele of type I Collagen), mechanism of the intra-nuclear fate of COL1A1 RNA in Osteogenesis Imperfecta (OI) Type I as well as the molecular basis of nanomelia, a heritable chondrodistrophy in chicken that was caused by premature stop codon within aggrecan gene. He published more than 80 papers in peer reviewed journals (63 in SCI and CC), 5 textbooks and several book chapters. His papers have been cited more than 1500 times. He was mentoring 9 PhD students who successfully completed its theses.He is also founder of International Society of Applied Biological Science (ISABS)

Prof. Dragan Primorac MD, PhD; Prof. Mladen Rakiæ, MD, PhD; Prof. Krešimir Rotim MD, PhD; Prof. Igor Boriæ MD, PhD; dr. Karlo Houra, MD, PhD; dr. Darko Peroviæ, MD; dr. Dubravka Bartolek Hamp MD, PhD.

Relevant Competencies and Experience: St. Catherine Specialty Hospital is a Center of Excellence for advanced diagnostics, spinal surgery with the treatment of painful vertebral conditions (pain management). St. Catharine Specialty Hospital, with an experienced and for the pain treatment trained medical staff, has five specialist-consulting clinics, radiological MRI diagnostics, five operating rooms, orthopaedics department, day hospital for outpatient surgery and post-anaesthesia care unit (PACU), standardized and equipped for 24-hour intensive supervision. A distinctive feature of the St. Catharine Specialty Hospital is its “Acute Pain Service Team”, an integrated multidisciplinary body which adheres to the World Health Organization Declaration that a “life without pain constitutes a fundamental human right”. The Hospital’s multidisciplinary Acute Pain Service (APS) team is there to synchronise the particular requirements of a patient experiencing a phase of acute pain (PCA) for receiving multimodal, regional (RA) or intravenous (i.v.) analgesia with the overall aims of their personal treatment, all the while actively involving every specialist in this single effort (surgeon, anaesthesiologist, pharmacologist and specialist for physiatry and rehabilitation). The fruit of these coordinated efforts is to enable immediate physical rehabilitation and enhance the progress of recuperation while maintaining minimal level of postoperative pain.

Main Tasks:
Recruiting patients for prospective study, collection of samples and clinical diagnostics Participant: WP2, WP3, WP4, WP5, WP6, WP7, WP8, WP9.